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A lipid used in the formation of lipid prodrug nanoassemblies lipid catechol-CIP-PBA LPNAs inhibit the formation of and disrupt preformed S. aureus biofilms and eradicate staphylococci in a mouse model of peritoneal S. aureus infection lipid catechol-BTZ LPNAs reduce tumor growth and increase survival in a 4T1 murine mammary carcinoma model
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A pyranocoumarin with diverse biological activities inhibits RANKL-induced osteoclastogenesis of primary mouse BMDMs at 10 UM and LPS-induced NO production in RAW 264.7 macrophages at 100 UM inhibits PAF-induced platelet aggregation in isolated rabbit platelet-rich plasma (IC50 50 UM) and contractions of isolated guinea pig ileum induced by histamine or leukotriene D4 (pD2s 4.84 and 4.34 respectively) decreases ovariectomy-induced bone loss in a mouse model of osteoporosis at 10 mg/kg reduces the number of tumors initiated by DMBA and promoted by TPA in a mouse two-stage model of skin carcinogenesis
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An FXR agonist induces luminescence in a reporter assay using HEK293T cells expressing human FXR (EC50 18 nM) decreases the serum levels of ALT and total cholesterol as well as hepatic inflammation fat levels and fibrosis in a mouse model of NASH induced by a high-fat diet and CCl4 at 1 3 or 10 mg/kg per day
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An internal standard for the quantification of psilocybin by GC- or LC-MS provided as a DEA exempt preparation intended for research and forensic applications
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A thiol-reactive fluorogenic reagent has been used to detect and quantify thiol-containing amino acids protein and tissue thiols and disulfide linkages ex/em 389/513 nm respectively
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Find it fast with Post-it Flags They make it simple to mark flag or highlight important information They stick securely remove cleanly and come in a wide variety of colors Draw attention to critical items or use them to index file or color code your work either at home work or in the classroom Color(s)- Assorted Brights Color Family- Multicolor Page Flags Dispenser- Pop-Up Color Assortment- Bright Blue Bright Green Bright Pink Bright Yellow
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An inhibitor of EGFRL858RT790M (IC50 1.1 nM) selective for EGFRL858RT790M over BTK wild-type EGFR FAK HER2 and HER4 (IC50s 213 226 255 392 and 704 nM respectively) but also inhibits wild-type EGFR containing an exon 19 deletion EGFRT790M containing an exon 19 deletion EGFRL585R EGFRG192A and EGFRL861Q (IC50s 1.3-12 nM) reduces tumor volume in a PDX mouse model of NSCLC at 25 and 50 mg/kg twice per day
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Each vial contains nNOS (rat) to be used as a standard for WB and electrophoresis. The enzyme has been carefully purified to exclude all unrelated proteins; may not be catalytically active.{1281}
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An analytical reference standard categorized as a precursor in the synthesis of fentanyl-related compounds intended for research and forensic applications
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A saponin with diverse biological activities inhibits the proliferation of and induces apoptosis in HeLa cells from 100-400 mg/L inhibits viral replication in cells infected with HSV-1 HCMV or influenza virus (IC50s 54 104 and 88 UM respectively) prevents the development of acute liver failure in a mouse model of LPS/D-galactosamine-induced acute liver injury at 5 mg/kg
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